Dr. Clark is currently Sr. Director of Research at Tripos, Inc., in St. Louis MO. Tripos produces computational chemistry and cheminformatics software, including Sybyl, Unity and SARNavigator, among others . The company also undertakes contract and collaborative research projects entailing development of new data analysis methods for drug discovery, customized data-sharing systems and library design, and carries out synthesis of generalized discovery and customized lead follow-up libraries.
Dr. Clark received his bachelor's and master's degrees from Ohio University in chemistry, and went on to earn his PhD in biochemistry from Cornell University, minoring in statistics and biometry. He then spent two years doing post-doctoral work in plant bioenergetics at Brookhaven National Laboratories. Dr. Clark came to St. Louis in 1984, where he spent the next ten years with Monsanto. His initial responsibilities involved research on plant physiology and herbicide modes of action, but he spent most of the last six of those years carrying out SAR-guided herbicide and fungicide synthesis.
Since joining Tripos in 1994, he has drawn on this broad range of experience in discovering and developing biologically active small molecules to expand the spectrum of software tools and analysis methodology available to others in the field. He has played a key role in the expansion of Tripos' world-renowned products for elucidating quantitative structure-activity relationships (QSARs) and molecular diversity, and has published extensively in these and related areas. Dr. Clark now conducts and directs research into new techniques for advanced QSAR, with a particular focus on those used in dealing with data from high-throughput screening (HTS) programs.
